Compositions of isoquinolines and polymeric dialdehydes for...

A - Human Necessities – 61 – K

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A61K 31/717 (2006.01) A23K 1/16 (2006.01) A23L 1/30 (2006.01) A61K 31/4745 (2006.01) A61K 31/718 (2006.01) A61K 31/721 (2006.01) A61K 31/78 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2536489

The present invention related to compositions including berberine or derivatives thereof of formula (1) (where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and X are as defined in claim 1) and/or polymeric dialdehyde chosen from compounds such as dialdehyde polysaccharides (such as oxidised cellulose (oxycellulose) or oxidized starch (oxystarch) or poly(acrolein/acrylic acid) for the treatment of gastrointestinal functional disorders and related conditions, including Irritable Bowel Syndrome; Inflammatory Bowel Disease; Colitis,Crohn~s disease and/or for promoting weight gainin animals including humans.

La présente invention concerne des compositions comprenant de la berbérine ou des dérivés de berbérine représentés par la formule (1) (dans laquelle R1, R2, R3, R4 , R5, R6, R7, R8 ,R9 ,R10 ,R11 , R12 et X sont comme définis dans la revendication 1) et/ou un dialdéhyde polymère pris parmi des composés tels que des polysaccharides de dialdéhyde (tels que la cellulose oxydée (oxycellulose) , l'amidon oxydé (oxyamidon) ou un poly(prop-2-énal/acide acrylique) pour le traitement de troubles gastro-intestinaux fonctionnels et états connexes, dont le syndrome du côlon irritable, la maladie intestinale inflammatoire, la colite, l'iléite régionale et/ou pour favoriser la prise de poids chez l'animal, dont l'homme.

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