C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/02 (2006.01) C07D 209/34 (2006.01)
Patent
CA 2736177
The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.
La présente invention concerne de nouvelles indolin-2-ones substituées par un groupe thiazole qui sont des inhibiteurs de CSCPK et de kinases apparentées; des procédés pour inhiber des cellules souches de cancer en utilisant un inhibiteur de kinase; des compositions pharmaceutiques comprenant ces composés; et des procédés d'utilisation de ces composés dans le traitement d'un trouble lié à une protéine kinase chez un mammifère; et des procédés de préparation de ces composés et de leurs intermédiaires.
Li Chiang Jia
Li Wei
Li Youzhi
Liu Ji-Feng
Rogoff Harry
Boston Biomedical Inc.
Gowling Lafleur Henderson Llp
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