A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/495 (2006.01) A61K 9/14 (2006.01)
Patent
CA 2307097
The present invention is concerned with novel pharmaceutical compositions of lipid lowering agents which can be administered to a mammal suffering from hyperlipidemia, obesitas or atherosclerosis, whereby a single such dosage form can be administered once daily, and in addition at any time of the day independently of the food taken in by said mammal. These novel compositions comprise particles obtainable by melt-extruding a mixture comprising a lipid lowering agent and an appropriate water-soluble polymer and subsequently milling said melt-extruded mixture.
L'invention concerne de nouvelles compositions pharmaceutiques d'hypolipémiants. Ces compositions peuvent être administrées à un mammifère souffrant d'hyperlipémie, d'obésité ou d'athérosclérose, la forme posologique permettant une adiministration quotidienne unique, à n'importe quelle heure du jour et indépendente de la prise d'aliments par ce mammifère. Ces nouvelles compositions comprennent de particules qui peuvent être obtenues par extrusion à chaud d'un mélange comprenant un hypolipémiant et un polymère approprié soluble à l'eau, suivie d'un broyage de ce mélange extrudé à chaud.
Baert Lieven
Verreck Geert
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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