Compositions of magnetic particles covered with...

Details Compositions of magnetic particles covered with... Compositions of magnetic particles covered with...

A - Human Necessities

61

K

A61K 49/18 (2006.01) C07F 9/38 (2006.01)

Patent

CA 2510531

The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, said acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, having formula (I) X-L-CH (PO¿3?H¿2?)¿2?, wherein: L represents an organic group connecting function X to function gem-bisphosphonate -CH(PO¿3?H¿2?)¿2?; X represents a chemical function that can react with a biovector and, optionally, the X functions of the aforementioned particles are fully or partially coupled to a biovector. The invention also relates to a method of preparing said compounds and to the use of same, particularly as a contrast agent for magnetic resonance imaging (IRM).

L'invention a pour objet une composition comprenant des particules magnétiques acides (p) à base d'un composé du fer, lesdites particules magnétiques acides (p) étant complexée par un ou plusieurs composés gem-bisphosphonate, de Formule (I): X-L-CH (PO3H2)2 dans laquelle: L représente un groupement organique reliant la fonction X à la fonction gem-bisphosphonate -CH(PO3H2)2; X représente une fonction chimique susceptible de réagir avec un biovecteur; lesdites fonctions X desdites particules étant éventuellement couplées en tout ou partie à un biovecteur. L'invention concerne également un procédé de préparation desdites compositions et leur utilisation, notamment comme produit de contraste pour l'Imagerie par Résonance Magnétique (IRM).

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