Compositions of microparticles and granules for oral...

Details Compositions of microparticles and granules for oral... Compositions of microparticles and granules for oral...

A - Human Necessities

23

K

A23K 1/00 (2006.01) A23K 1/175 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2659948

Microparticles or granules intended for use in the zootechnical field, constituted by a core which contains a substance having a pharmacological action, a food supplement or a diagnostic medium, intimately mixed or adsorbed with a hydrated silicate of magnesium, aluminum, calcium and sodium (smectite, montmorillonite or bentonite); the core is coated with a double fatty layer constituted by two fats or waxes, of which the one having the highest melting point constitutes the inner layer while the one having the lowest melting point is arranged so as to form the outer layer. The ability to control release effectively and accordingly reduce rumen degradation of active substances which contain a cationic or an anionic chemical function, such as for example choline chloride, lysine hydrochloride, calcium chloride, citric acid, ascorbic acid or nicotinic acid is determined by the synergistic action of two phenomena: an interaction between the active substance and the other component of the core, and the barrier effect of the double fat layer. Taken individually, the two phenomena are unable to apply effective control over the release of the active substance.

L'invention concerne des microparticules ou granulés destinés à une utilisation dans le domaine zootechnique, constitués par un noyau qui contient une substance ayant une action pharmacologique, un supplément alimentaire ou un milieu de diagnostic, intimement mélangés ou adsorbés avec un silicate hydraté de magnésium, d'aluminium, de calcium et de sodium (smectite, montmorillonite ou bentonite) ; le noyau est enrobé d'une double couche grasse constituée de deux graisses ou cires, parmi lesquelles celle ayant le point de fusion le plus élevé constitue la couche interne tandis que celle ayant le point de fusion le plus bas est disposée de façon à former la couche externe. L'aptitude à contrôler la libération de façon efficace et, en conséquence, à réduire la dégradation dans le rumen de substances actives qui contiennent une fonction chimique cationique ou anionique, telles que, par exemple, le chlorure de cholène, l'hydrochlorure de lysine, le chlorure de calcium, l'acide citrique, l'acide ascorbique ou l'acide nicotinique, est déterminée par l'action synergique de deux phénomènes : une interaction entre la substance active et l'autre composant du noyau, et l'effet barrière de la double couche grasse. Pris individuellement, les deux phénomènes sont incapables d'appliquer un contrôle efficace sur la libération de la substance active.

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