C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/551 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 491/113 (2006.01)
Patent
CA 2643677
Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastro-intestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.
L'invention concerne des composés de diarylméthylpipérazine utiles en tant que composés opioïdes pour les récepteurs mu et/ou delta, ne présentant pas d'effets secondaires centraux. Les compositions pharmaceutiques contenant ces composés sont utiles dans des indications diverses, périphériques ou à médiation non centrale, notamment la douleur neuropathique et à médiation périphérique, les troubles de l'appareil génito-urinaire, l'hyperactivité vésicale, l'incontinence urinaire, les troubles sexuels, l'éjaculation précoce, la toux, l'oedème pulmonaire, les troubles cardiaques, la cardioprotection, les troubles gastro-intestinaux, la diarrhée, le syndrome du côlon irritable, la distension fonctionnelle, l'immuno-modulation et l'activité anti-tumorale.
Biciunas Kestutis P.
Chang Kwen-Jen
Jan Shyi-Tai
Ma Xin
Biciunas Kestutis P.
Chang Kwen-Jen
Davis Llp
Jan Shyi-Tai
Ma Xin
LandOfFree
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