Compositions of nucleic acid and viscosity-increasing...

Details Compositions of nucleic acid and viscosity-increasing... Compositions of nucleic acid and viscosity-increasing...

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 31/70 (2006.01) A61K 47/10 (2006.01) A61K 47/30 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2210132

Compositions and methods for administering nucleic acid compositions in vitro to cells in culture or in vivo to an organism whereby the uptake of nucleic acids is enhanced are provided. Various compositions, including thermo- reversible gels, are utilized to increase the viscosity of an administered nucleic acid formulation, thereby prolonging the localized bioavailability of the administered nucleic acid.

L'invention concerne des compositions à base d'acides nucléiques et des procédés pour administrer lesdites compositions in vitro à des cellules en culture ou bien in vivo à un organisme; ces compositions permettent d'améliorer l'absorbtion des acides nucléiques. On utilise diverses compositions, y compris des gels thermoréversibles, pour augmenter la viscosité d'une préparation à base d'acides nucléiques destinée à être administrée, ce qui permet de prolonger la biodisponibilité localisée des acides nucléiques.

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