Compositions of orthogonal lysyl-trna and aminoacyl-trna...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/52 (2006.01) A61K 31/7088 (2006.01) A61K 35/74 (2006.01) A61K 38/53 (2006.01) C12N 1/20 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01) C12P 21/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2531146

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.

L'invention concerne des compositions et des procédés de production de composants d'un système biosynthétique protéique qui comprend des lysyl-tARN orthogonaux, des lysyl-aminoacyl-tARN orthogonal-synthétases, des paires orthogonales de lysyl-tARN/synthétases. Selon l'invention, des homoglutamines sont incorporées à des protéines en réponse à un codon à quatre bases. L'invention concerne également des procédés d'identification de ces paires orthogonales, ainsi que des procédés de production de protéines avec des homoglutamines faisant appel à ces paires orthogonales.

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