C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) A61K 31/7088 (2006.01) A61K 35/74 (2006.01) A61K 38/53 (2006.01) C12N 1/20 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01) C12P 21/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2531146
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.
L'invention concerne des compositions et des procédés de production de composants d'un système biosynthétique protéique qui comprend des lysyl-tARN orthogonaux, des lysyl-aminoacyl-tARN orthogonal-synthétases, des paires orthogonales de lysyl-tARN/synthétases. Selon l'invention, des homoglutamines sont incorporées à des protéines en réponse à un codon à quatre bases. L'invention concerne également des procédés d'identification de ces paires orthogonales, ainsi que des procédés de production de protéines avec des homoglutamines faisant appel à ces paires orthogonales.
Anderson J. Christopher
Santoro Stephen
Schultz Peter G.
Wu Ning
Fetherstonhaugh & Co.
The Scripps Research Institute
LandOfFree
Compositions of orthogonal lysyl-trna and aminoacyl-trna... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions of orthogonal lysyl-trna and aminoacyl-trna..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions of orthogonal lysyl-trna and aminoacyl-trna... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1687386