Compositions of p-hydroxybenzoic acid esters and methods of...

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A61K 31/415 (2006.01)

Patent

CA 1177756

COMPOSITIONS OF p-HYDROXYBENZOIC ACID ESTERS AND METHODS OF PREPARATION AND USE Abstract of the Disclosure A composition having broad spectrum antimicrob- ial activity and being freeze and heat stable is com- prised of a clear solution containing up to approximately 90% by weight of a eutectic mixture of three or more lower alkyl esters of p-hydroxybenzoic acid such as iso- propyl p-hydroxybenzoate, isobutyl p-hydroxybenzoate and n-butyl p-hydroxybenzoate in a ratio between approximate- ly 1:1:1 to 4:2:2, respectively, approximately 10% to 90% by weight of a "Glydant" solution (composed of 55% 1,3-bis(hydroxymethyl)- 5,5-dimethylhydantoin and 45% water) and at least approximately 0.5% by weight based on the weight of the eutectic mixture and the "Glydant" solution of an anionic surfactant. The latter, for exam- ple, may be dioctyl sodium sulfosuccinate, sodium lauryl sulfate or the ammonium or sodium salt of sulfated nonyl- phenoxypoly(ethyleneoxy) ethanol.

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