C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/08 (2006.01) A61K 31/7008 (2006.01) A61K 31/722 (2006.01) A61P 17/02 (2006.01) A61P 19/00 (2006.01) C08L 5/08 (2006.01)
Patent
CA 2611453
The present invention relates to compositions comprising biologically active chitinous oligomers and their endotoxin purified and partially deacetylated chitin polymer precursors, and their use in pharmaceutical compositions, biomaterial compositions, medical devices, and processes to produce the said oligomers. More specifically the present invention relates to novel compositions and processes to produce such compositions. The compositions include therapeutic hetero polymer and hetero oligomer compositions compricing specific sequences of N-acetyl glucosamine and glucosamine, developed to optimize chemical and structural features which are important for the therapeutic activity of these compositions. In addition, the present invention provides methods to use degree of deacetylation of a partially deacetylated chitin polymer in order to modulate physical and biological parameters in a calcium phosphate composite for bone implant applications.
La présente invention concerne des compositions comprenant des oligomères chitiniques biologiquement actifs et des précurseurs de polymères chitiniques purifiés de leur endodoxine et partiellement désacétylés. L'invention concerne également leur utilisation pour des compositions pharmaceutiques, des compositions de biomatériaux, des dispositifs médicaux, et des procédés de production de ces oligomères. L'invention concerne plus particulièrement de nouvelles compositions et de nouveaux procédés pour produire de telles compositions. Les compositions comprennent des chito-oligomères thérapeutiques N-acétyle-glucosamine et de glucosamine, mis au point pour optimiser les caractéristiques chimiques et structurelles qui sont importantes pour tous les aspects de leur activité biologique. En outre, l'invention concerne des procédés permettant d'utiliser le degré de désacétylation d'un polymère chitinique partiellement désacétylé pour moduler les paramètres physiques et biologiques dans un composite au phosphate de calcium destiné à des applications d'implants osseux.
Bahrke Sven
Chuen How Ng
Einarsson Jon M.
Gislason Johannes
Genis Ehf.
Ridout & Maybee Llp
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