Compositions of pd-1 antagonists and methods of use

Details Compositions of pd-1 antagonists and methods of use Compositions of pd-1 antagonists and methods of use

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2734908

Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.

L'invention concerne des méthodes de traitement du cancer et des maladies infectieuses au moyen d'un schéma thérapeutique consistant à administrer un composé destiné à réduire la transduction de signal inhibiteur dans les lymphocytes T, associé à un agent de potentialisation, tel que la cyclophosphamide, pour produire des réponses puissantes induites par les lymphocytes T. L'invention concerne également des compositions contenant lesdits antagonistes de PD-1 et agents de potentialisation, utiles dans les méthodes selon l'invention.

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