A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2687028
The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild- type PAL. The invention provides compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic purposes, including the treatment of cancer.
L'invention concerne des variants de phénylalanine ammoniac/lyase (PAL) produits par des procaryotes, de tels variants procaryotiques de PAL ayant une plus grande activité de conversion et/ou une immunogénicité réduite par rapport à un de type sauvage. L'invention fournit des compositions de PAL procaryotique de fragments, mutants, variantes ou analogues biologiquement actifs et celui-ci, ainsi que des procédés pour la production, la purification, et l'utilisation de telles compositions à des fins thérapeutiques, y compris le traitement du cancer.
Bell Sean M.
Fitzpatrick Paul A.
Kakkis Emil D.
Muthalif Mubarack
Okhamafe Augustus O.
Biomarin Pharmaceutical Inc.
Osler Hoskin & Harcourt Llp
LandOfFree
Compositions of prokaryotic phenylalanine ammonia-lyase and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions of prokaryotic phenylalanine ammonia-lyase and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions of prokaryotic phenylalanine ammonia-lyase and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2032732