Compositions of protein receptor tyrosine kinase inhibitors

Details Compositions of protein receptor tyrosine kinase inhibitors Compositions of protein receptor tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61P 29/00 (2006.01) C07D 403/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2746220

The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF recptor TrkA.

La présente invention porte sur de nouveaux composés hétérocyliques substitués synthétiques et sur des compositions pharmaceutiques contenant ceux-ci qui sont capables d'inhiber ou d'antagoniser une famille de tyrosine kinases de récepteur, de kinases apparentées à la tropomysosine (Trk), en particulier le récepteur de facteur de croissance neural (NGF), TrkA. L'invention porte en outre sur l'utilisation de tels composés pour le traitement et/ou la prévention de la douleur, d'un cancer, d'une resténose, de l'athérosclérose, du psoriasis, d'une thrombose ou d'une maladie, d'un trouble ou d'une lésion lié à une dysmyélinisation ou démyélinisation ou d'une maladie ou d'un trouble associé à des activités anormales du récepteur TrkA au NGF.

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