A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01) A61P 9/02 (2006.01) C12N 15/10 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2542874
The present invention provides methods and compositions for stabilizing dried nucleic acids with carbohydrates such as non-reducing sugars, polysaccharides, and reducing sugars. Preferably, the stabilized nucleic acids are coated on a microprojection member for transdermal delivery. The invention further provides compositions and methods that involve the use of DNase inhibitors to stabilize dried nucleic acids delivered directly into bodily tissues.
La présente invention concerne des procédés et des compositions pour stabiliser des acides nucléiques séchés avec des hydrates de carbone tels que des sucres non réducteurs, des polysaccharides, et des sucres réducteurs. De préférence, les acides nucléiques stabilisés sont revêtus d'un élément de microprojection pour administration transdermique. L'invention a également pour objet des compositions et des procédés qui impliquent l'utilisation d'inhibiteurs d'ADNase pour stabiliser des acides nucléiques séchés administrés directement dans les tissus corporels.
Ameri Mahmoud
Cormier Michel J. N.
Widera Georg
Alza Corporation
Borden Ladner Gervais Llp
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