C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) A61K 31/70 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) C07K 7/04 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C07K 17/02 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2190972
The inventions provides compositions and a novel method of immunization directed against released transactivating proteins of certain target viruses that are taken up by other cells, including particularly HIV and other integrating and chronically infecting viruses. The method employs TAT immunogens, which are capable of eliciting high titer antibody to the native TAT protein, especially the regions involved in cellular uptake.
Compositions et nouveau procédé d'immunisation contre des protéines de transactivation libérées de certains virus cibles qui sont prises par d'autres cellules, comprenant notamment le VIH et d'autres virus intégrateurs et chroniquement infectieux. On utilise dans ce procédé des immunogènes TAT qui sont capables d'induire un anticorps à titre élevé dirigé contre une protéine TAT naturelle et plus spécifiquement les régions impliquées dans le captage cellulaire.
Culler Michael D.
Goldstein Gideon
Shenbagamurthi Ponniah
Goldstein Gideon
Gowling Lafleur Henderson Llp
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