Compositions of trna and uses thereof

Details Compositions of trna and uses thereof Compositions of trna and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12P 19/34 (2006.01) C12P 21/00 (2006.01) C12P 13/04 (2006.01) C12P 13/22 (2006.01)

Patent

CA 2618878

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA~s, orthogonal aminoacyl- tRNA synthetases, and orthogonal pairs of tRNA~s /synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.

L~invention concerne des compositions et des méthodes pour produire des composants de machinerie biosynthétique de protéine qui incluent des ARNt orthogonaux, des synthétases d'ARNt-aminoacyl orthagonales, et des pairs orthogonales ARNt/synthétases. Elle concerne aussi des méthodes pour identifier ces paires orthogonales ainsi que des méthodes pour produire des protéines qui utilisent ces paires orthogonales.

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