Compositions, systems, and methods for creating in situ,...

A - Human Necessities – 61 – L

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A61L 24/04 (2006.01) A61L 24/10 (2006.01)

Patent

CA 2435050

Disclosed is a biocompatible and biodegradable material to be applied to seal a vascular puncture comprising: (A) a buffered protein solution having a pH value of between about 7 and about 10 and comprising recombinant or natural human serum albumin at a concentration of about 25% or less, and (B) a polymer solution comprising cross-linkable polyethylene glycol)(PEG) derivative with a functionality of at least three, wherein, upon mixing, the buffered protein solution and the polymer solution cross-link to form a solid matrix that seals the vascular puncture without use of a photo- initiator and ultraviolet light energy. The material safely, quickly and reliably arrests or controls fluid leakage in body tissues through the application of pressure and without interaction with the patient's coagulation pathways.

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