Compositions, systems and methods for treatment of defects...

A - Human Necessities – 61 – F

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A61F 2/04 (2006.01) A61F 2/06 (2006.01)

Patent

CA 2587335

Methods and systems are provided for treating a vascular structure having a defect, for example, a cerebral artery having a weakened wall that has formed an aneurysm. The methods include substantially entrapping a quantity of blood within a vascular defect, and introducing a quantity of a crosslinking agent, for example as a liquid solution, into the entrapped blood. The crosslinking agent is a compound in which each molecule of the compound has at least two nucleophilic-reactive functional groups. The crosslinking agent is allowed to combine with and react with the substantially entrapped blood, and a substantially solid mass made of crosslinked blood is formed within the defect.

La présente invention a trait à de procédés et des systèmes pour le traitement d'une structure vasculaire présentant une anomalie, par exemple, une artère cérébrale présentant une paroi affaiblie qui a formé un anévrisme. Le procédés comprennent le piégeage substantiel d'une quantité de sang dans l'anomalie vasculaire, et l'introduction d'une quantité d'un agent de réticulation, par exemple sous la forme d'une solution liquide, dans le sang piégé. L'agent de réticulation est un composé dans lequel chaque molécule du composé comporte au moins deux groupes fonctionnels à réaction nucléophile. L'agent de réticulation est amené à se combiner et à réagir avec le sang sensiblement piégé, et une masse sensiblement solide constituée de sang réticulé est formée au sein de l'anomalie.

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