Compositions that include a hydrophobic compound and a...

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/12 (2006.01) A61K 49/18 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2683590

Various compositions that include a hydrophobic compound and a polymer conjugate are described herein. The compositions can include a polymer conjugate, a first hydrophobic drug, and a second hydrophobic drug. The polymer conjugates of the compositions described herein are capable of conjugating to a number of agents, such as imaging agents, targeting agents, stabilizing agents and/or drugs. Additionally, the polymer conjugates described herein can form nanoparticles that effectively solubilize the agent in an aqueous system by dispersing it at a molecular level, thus increasing the functionality and/or bioavailability of the agent. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications, including delivery of an agent to specific parts of the body.

L'invention concerne la préparation de diverses compositions contenant un composé hydrophobe et un conjugué polyamino acide. Les compositions de l'invention sont utilisées dans diverses applications d'administration de médicaments, de biomolécules et d'agents d'imagerie.

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