Compositions that specifically bind to colorectal cancer...

A - Human Necessities – 61 – K

Patent

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Details

A61K 51/08 (2006.01) A61K 31/70 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 7/08 (2006.01) C07K 14/24 (2006.01) C12Q 1/68 (2006.01) G01N 33/534 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2174928

Conjugated compounds which comprise an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radioactive active moiety are disclosed. Methods of treating an individual suspected of suffering from metastasized colorectal cancer are disclosed. Methods of radioimaging metastasized colorectal cancer cells are disclosed. In vitro methods, kits and reagents are disclosed for determining whether or not an individual has metastasized colorectal cancer cells, for determining whether tumor cells are colorectal in origin and for analyzing tissue samples from the colon tissue to evaluate the extent of metastasis of colorectal tumor cells.

L'invention concerne des composés conjugués comprenant une fraction de fixation à un récepteur de ST et une fraction active radiostable. Elle concerne également des compositions pharmaceutiques comprenant ledit composé conjugué constitué par une fraction de fixation à un récepteur de ST et par une fraction active radiostable ou par une fraction de fixation à un récepteur de ST et par une fraction active radioactive. Elle concerne également des procédés de traitement d'un patient susceptible d'être atteint d'un cancer colo-rectal métastasé, ainsi que des procédés d'imagerie de cellules cancéreuses colo-rectales métastasées. Elle décrit des procédés in vitro, des kits et des réactifs servant à déterminer si le patient est porteur de cellules cancéreuses colo-rectales métastasées, si les cellules cancéreuses sont d'origine colo-rectale et à analyser des spécimens de tissu provenant du colon, afin d'évaluer l'étendue des métastases des cellules cancéreuses colo-rectales.

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