Compositions to enhance the cytoprotective effects of...

Details Compositions to enhance the cytoprotective effects of... Compositions to enhance the cytoprotective effects of...

A - Human Necessities

61

K

A61K 38/06 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2276146

A method is provided for enhancing the cytoprotective effect of polycyclic phenolic compounds on a population of cells that involves the steps of administering a combination of polycyclic phenolic compounds and anti-oxidants to achieve an enhanced effect that is greater than the use of either compound administered separately under otherwise similar conditions. An example of an anti-oxidant for use in the method is glutathione and an example of a polycyclic phenolic compound is an estrogen compound. The cytoprotective effect occurs in a variety of different cell types including neuronal cells and cells of the vascular system.

L'invention concerne un procédé permettant d'améliorer l'effet cytoprotecteur de composés polycycliques phénoliques sur une population de cellules. Ce procédé consiste à administrer des composés polycycliques phénoliques combinés à des antioxydants afin d'obtenir une protection améliorée par rapport à l'utilisation de l'un desdits composés qui serait administré séparément dans des conditions similaires. L'antioxydant utilisé pour ce procédé peut par exemple être du glutathion (GSH), tandis que le composé polycyclique phénolique peut être un composé oestrogène. L'effet cytoprotecteur se produit chez différents types de cellules, notamment les cellules neuronales et les cellules du système vasculaire.

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