Compositions useful as inhibitors of gsk-3

Details Compositions useful as inhibitors of gsk-3 Compositions useful as inhibitors of gsk-3

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/519 (2006.01) A61K 31/55 (2006.01) A61K 45/00 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 9/14 (2006.01) A61P 11/06 (2006.01) A61P 15/10 (2006.01) A61P 17/14 (2006.01) A61P 25/00 (2006.01) A61P 25/08 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) A61P 27/06 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01) A61P 35/04 (2006.01) A61P 37/06 (2006.01) A61P 41/00 (2006.01) A61P 43/00

Patent

CA 2444598

The present invention provides compounds of formula I:or a pharmaceutically acceptable derivative thereof, wherein X is oxygen or sulfur; Y is -S-, -O- or -NR1-; and R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of GSK-3 mammalian protein kinase. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatement and prevention of various disorders, such as diabetes and Alzheimer's disease.

L'invention concerne des composés représentés par la formule (I) ou un dérivé de ceux-ci pharmaceutiquement acceptable. Dans cette formule, X représente oxygène ou soufre; Y représente -S-, -O- ou -NR1-; et R2, R3, et R4 sont tels que décrits dans la spécification. Ces composés sont utilisés comme inhibiteurs de protéine kinase, notamment comme inhibiteurs de la protéine kinase GSK-3 de mammifère. L'invention concerne également des compositions pharmaceutiques contenant ces inhibiteurs, et des méthodes permettant d'utiliser ces compositions pour traiter et prévenir différents troubles, tels que les diabètes et la maladie d'Alzheimer.

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