Compositions useful as inhibitors of protein kinases

Details Compositions useful as inhibitors of protein kinases Compositions useful as inhibitors of protein kinases

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/495 (2006.01) A61K 31/503 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) C07D 237/00 (2006.01) C07D 249/00 (2006.01)

Patent

CA 2510534

The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of PIM-1, CDK-2, GSK-3, and SRC mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

L'invention concerne un composé représenté par la formule (I), ou un sel pharmaceutiquement acceptable de celle-ci. Ces composés sont des inhibiteurs des protéine kinases, en particulier des protéine kinases de mammifères PIM-1, CDK-2, GSK-3, et SRC. L'invention concerne également des compositions pharmaceutiquement acceptables contenant les composés décrits et des méthodes d'utilisation de ces composés et compositions pour le traitement de divers troubles dans lesquels les protéine kinases interviennent comme médiateurs.

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