C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/02 (2006.01) A61K 31/395 (2006.01) A61K 38/04 (2006.01) C07D 255/02 (2006.01) C07D 401/06 (2006.01) C07K 5/06 (2006.01) C07K 7/02 (2006.01) C07K 16/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2106982
2106982 9216548 PCTABS00016 Compositions which are immunologically crossreactive with antibodies are provided, together with preparative and therapeutic methods therefor. The compositions preferably comprise a plurality of covalently bound synthetic compounds, at least one of which is individually crossreactive with at least one complementarity determining region (CDR) of the antibody. Preferred processes for preparing the immunologically crossreactive compounds comprise identifying chemical functionality such as hydroxyl groups in the CDR which participates in at least one immunological binding phenomena, determining the three-dimensional positioning of the chemical functionality, and synthesizing a compound which comprises substantially the same chemical functionality as the CDR and which has at least one conformation wherein the three-dimensional positioning of the chemical functionality is substantially identical to the three-dimensional positioning of the chemical functionality of the CDR.
Green Mark I.
Kahn Michael
Saragovi Horacio U.
Borden Ladner Gervais Llp
Green Mark I.
Kahn Michael
Saragovi Horacio U.
The Trustees Of The University Of Pennsylvania
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