Compositions with antigens adsorbed to calcium phosphate

Details Compositions with antigens adsorbed to calcium phosphate Compositions with antigens adsorbed to calcium phosphate

A - Human Necessities

61

K

A61K 39/02 (2006.01) A61K 39/095 (2006.01)

Patent

CA 2628084

Calcium phosphate is used as an adjuvant, with a high degree of antigen adsorption to the adjuvant. The invention is particularly useful for adjuvanting conjugated capsular saccharide antigens. Buffers, such as phosphate or histidine buffers, can advantageously be used in combination with the calcium phosphate, and compositions may have a pH in the range of 5.5 to 7.5.

Le phosphate de calcium est utilisé comme adjuvant avec un degré élevé d'adsorption d'antigènes par l'adjuvant. L'invention convient particulièrement pour utiliser des antigènes saccharidiques conjugués d'enveloppe comme adjuvants. Des tampons, tels que des tampons de phosphate ou d'histidine, peuvent être avantageusement être combinés au phosphate de calcium et les compositions peuvent présenter un pH de 5,5 à 7,5.

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