Compositions with controlled pharmacokinetics

Details Compositions with controlled pharmacokinetics Compositions with controlled pharmacokinetics

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2654529

The invention encompasses methods for reducing food effect in a drug which exhibits such food effect by preparing a formulation comprising a drug which exhibits food effect and at least one biodegradable binder or lipophilic binder. The invention also encompasses a method for preparing a formulation having a target food effect comprising (a) determining a target food effect; and (b) combining an API which exhibits food effect and a sufficient amount of (i) at least one biodegradable binder, (ii) at least one lipophilic binder, or (iii) combinations thereof, to produce a formulation having the target food effect.

L'invention concerne des procédés de réduction de l'effet sur les aliments d'un médicament qui présente un tel effet sur les aliments par préparation d'une formulation comprenant un médicament qui présente un effet sur les aliments et au moins un liant biodégradable ou un liant lipophile. L'invention concerne également un procédé de préparation d'une formulation ayant un effet ciblé sur les aliments, comprenant (a) la détermination d'un effet ciblé sur les aliments ; et (b) le mélange d'un API présentant un effet sur les aliments et d'une quantité suffisante de (i) au moins un liant biodégradable, (ii) au moins un liant lipophile ou (iii) leur mélange, afin d'obtenir une formulation ayant l'effet ciblé sur les aliments.

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