Compositions with enhanced oral bioavailability

Details Compositions with enhanced oral bioavailability Compositions with enhanced oral bioavailability

A - Human Necessities

61

K

A61K 47/10 (2006.01) A61K 31/475 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/34 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2397781

The present invention describes the use of polysaccharides, surfactants, and dendrimers as bioavailability enhancers for oral pharmaceutical compositions. These substances exhert an inhibitory action of the gastrointestinal pump efflux proteins, such as the P-glycoprotein and the MDR protein, responsible for poor drug bioavailability and multidrug resistance. The formulations herein described comprise a medicinally active substance in association with said polysaccharides, surfactants, and dendrimers. They are well tolerated, are not absorbed by the gastrointestinal tract, and increase the bioavailability and the activity of orally administered medicaments, like e.g. antineoplastic, antiviral, antibiotic, or antidepressant medicaments.

L'invention concerne l'utilisation de polysaccharides, de tensioactifs, et de dendrimères en tant que stimulateurs de la biodisponibilité de compositions pharmaceutiques à administration orale. Ces produits exercent une action inhibitrice sur les pompes à efflux gastro-intestinales telles que la P-glycoprotéine et la protéine MDR, responsables d'une biodisponibilité amoindrie des médicaments et d'une multirésistance aux médicaments. Les formulations décrites comprennent un composant médicinalement actif associé à ces polysaccharides, tensioactifs et dendrimères. Elles sont bien tolérées, ne sont pas absorbées par le tractus gastro-intestinal, et augmentent la biodisponibilité et l'action de médicaments administrés par voie orale, tels que les antinéoplasiques, les antiviraux, les antibiotiques ou les antidépresseurs.

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