Compouds effective in inducing cell differentiation and...

Details Compouds effective in inducing cell differentiation and... Compouds effective in inducing cell differentiation and...

C - Chemistry, Metallurgy

07

C

167/125, 167/147

C07C 401/00 (2006.01) A61K 31/59 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1340615

This invention provides novel side chain homologs of 1.alpha.,25-dihydroxyvitamin D3 which exhibit enhanced and highly selective activity in inducing differentiation of malignant cells. It also provides a general method of synthesis applicable to the preparation of a variety of vitamin D side chain analogs, and a method of treatment of neoplastic diseases which takes advantage of the selective differentiation activity of the new vitamin D homologs.

597715

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