Compound

Details Compound Compound

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07J 31/00 (2006.01) C07J 43/00 (2006.01) C12N 15/10 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2465455

The present invention provides a delivery vehicle for a therapeutic agent comprising a modified lipid and a therapeutic agent; wherein the modified lipid comprises a lipid and a delivery, targeting or stabilising moiety (DTS moiety); wherein the lipid is linked to the DTS moiety via a linker which is stable in biological fluid and which is unstable in defined conditions; and wherein the DTS moiety is linked to the lipid alter formation of a complex of lipid and therapeutic agent.

La présente invention concerne un véhicule d'apport destiné à un agent thérapeutique comprenant un lipide modifié et un agent thérapeutique. Ce lipide modifié comprend un lipide et une fraction de ciblage ou de stabilisation (fraction DTS). Ce lipide est lié à cette fraction DTS via un lieur qui est stable dans un fluide biologique et qui est instable dans des conditions définies. Cette fraction DTS est liée au lipide après la formation d'un complexe de lipide et d'agent thérapeutique.

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