Compound, arugomycin

Details Compound, arugomycin Compound, arugomycin

C - Chemistry, Metallurgy

07

H

195/90, 260/208.

C07H 15/24 (2006.01) C07H 15/252 (2006.01) C12P 19/56 (2006.01)

Patent

CA 1207693

ABSTRACT OF THE DISCLOSURE An anthracycline compound, Arugomycin, having the physicochemical properties set forth below is produced by aerobically cultivating an Arugomycin-producing Streptomyces strain in a suitable culture medium, and recovering from the culture the anthracycline compound, Arugomycin. (1) Color and form: Orange powder (2) Melting point: 207 to 213°C (decomposed) (3) Specific rotatory power: [.alpha.]? = +112° (C: 0.1, chloroform:methanol = 9:1) (4) Elementary analysis (%): Image (5) Ultraviolet and visible absorption spectrum: as shown in FIG. 1. Image CH3OH 235(363), 258(167), 292(61), 476(104) 0.1N HCl +CH3OH 235(387), 258(159), 292(61), 468(110) 0.1N NaOH +CH3OH 239(302), 294(41), 543(88) (6) Infrared absorption spectrum (as measured by the potassium bromide method): as shown in FIG. 2. (7) Solubility in solvent: Easily soluble in a chloroforrn-methanol mixture, dimethyl sulfoxide, pyridine, and basic water. Soluble in chloroform, methanol, ethyl acetate, methyl ethyl ketone, butanol, butyl acetate, ethanol, acetone, and acidic water. Sparingly soluble in water. (8) Thin layer chromatography (using "Silica Gel 60F254" plate supplied by Merck & Co., Inc.): Image (9) NMR spectrum (400 MHz, in deuterochloroform- deuteromethanol): as shown in FIG. 3. (10) Molecular weight (SIMS): m/z 1694(M+H)

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