Compound profiling devices, systems, and related methods

Details Compound profiling devices, systems, and related methods Compound profiling devices, systems, and related methods

G - Physics

01

N

G01N 35/00 (2006.01) C12M 3/00 (2006.01)

Patent

CA 2601704

High throughput compound profiling systems, and related devices and sub- systems that can be used to perform various compound profiling processes are provided. These systems typically include work perimeters (202, 204, 206) that are organized for optimum efficiency and processing accuracy. Further, these systems are readily adaptable for performing a wide array of assays, as many different system components are easily incorporated or interchangeable in a particular system. System components that are provided by the invention include cell culture dissociators, which can be used, e.g., to effect cell wetting, dissociation, and/or agitation applications. In some embodiments, these cell culture dissociators are included as components of automated cell culture passaging stations. Dispensing devices that permit on- the- fly fluid temperature regulation are also provided. In addition, various compound profiling methods, cell dissociation methods, uniform cell concentration dispensing methods, among other processes, are also provided.

L'invention porte sur des systèmes de profilage de composés à haut débit, et sur des dispositifs et sous-systèmes liés qui peuvent être utilisés pour effectuer divers processus de profilage de composés. Lesdits systèmes comprennent généralement des périmètres de travail qui sont organisés pour une efficacité et une précision de traitement optimales. En outre, les systèmes de l'invention peuvent facilement être adaptés afin d'effectuer une large gamme d'analyses, étant donné que de nombreux composants différents du système sont faciles à intégrer dans un système particulier ou sont interchangeables. Les composants du système de l'invention comprennent des dissociateurs de culture cellulaire qui peuvent être utilisés, par exemple, pour effectuer une humidification des cellules, une dissociation, et/ou pour des applications d'agitation. Dans certains modes de réalisation, les dissociateurs de culture cellulaire sont inclus comme composants de postes de passage de cultures cellulaires automatisés. L'invention se rapporte également à des dispositifs de délivrance qui permettent une régulation "au vol" de la température du liquide. L'invention concerne aussi divers procédés de profilage de composés, de dissociation de cellules, de délivrance de concentrations cellulaires uniformes, entre autres.

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