Compounds

Details Compounds Compounds

C - Chemistry, Metallurgy

07

D

167/208, 260/292

C07D 401/06 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2012998

Abstract B2601/Abs A compound, or a solvate or salt thereof, of formula (I): Image (I) in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring; R1 and R2 are independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl or C4-12 cycloalkylalkyl groups, or together form a C2-8 branched or linear polymethylene or C2-6 alkenylene group, optionally substituted with a hetero-atom, R3 is hydrogen , C1-6 alkyl or phenyl, or R3 together with R1 form a -(CH2)3- or -(CH2)4- group; R4 and R5 are independently hydrogen, hydroxyl, halogen, C1-6 alkyl or aryl, provided both R4 and R5 are not simultaneously hydrogen; and p is an integer from 1 to 4, is useful for the treatment of pain or hyponatraemic disease states.

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