C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/253
C07D 239/95 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2015981
11992/22002/11 Abstract COMPOUNDS Compounds of structure Image (I) in which R1 is hydroxy, hydroxyC1-4alkyl, hydroxyC1-4alkoxy, carboxyC1-4alkoxy, C1-4alkoxyC1-4alkoxy, O(CH2)mHet, C1-4alkylNR6R7 or O(CH2)mNR6R7 in which m is 2 to 4 and R6 and R7 are the same or different and are each hydrogen, C1-4alkyl, Het, or -(CH2)nAr where n is 0 to 4, Ar is an optionally substituted phenyl ring, m is 2 to 4 and Het is an optionally substituted heterocyclic ring, or R6 and R7 together with the nitrogen to which they are attached form a saturated or unsaturated ring optionally containing one or more further heteroatoms; R2 and R3 and R4 and R5 are the same, or different and are each hydrogen, C1-4alkyl, -(CH2)nAr in which n is 0 to 4 and Ar is an optionally substituted phenyl ring, or R2 and R3 together with the nitrogen atom to which they are attached form a saturated or unsaturated ring optionally containing one or more further heteroatoms process for their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of gastric acid secretion.
Brown Thomas H.
Ife Robert J.
Keeling David J.
Leach Colin A.
Brown Thomas H.
Gowling Lafleur Henderson Llp
Ife Robert J.
Keeling David J.
Leach Colin A.
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