Compounds

C - Chemistry – Metallurgy – 08 – F

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167/206, 402/526

C08F 126/00 (2006.01) A61K 31/785 (2006.01) C08F 8/44 (2006.01)

Patent

CA 2016836

Abstract Compounds Polymers of structure : (I) Image in which X is CH2, CO or CHOH; Z is H or a group + X(CH2)nNR1R2R3; n is 1 to 20; R1 and R2 are the same or different and are each C1-4alkyl; R3 is C1-20alkyl; or R1, R2 and R3 together with the nitrogen atom to which they are attached form a ring, optionally containing one or more further heteroatoms, and optionally being substituted with a C1-4alkyl group; a, b and c are numbers which indicate the relative molar percentages of the units present in a random distribution in said polymer, (b) being from about 0.5 to about 10 molar percent, and (c) being from about 30 to about 99 molar percent; m is a number indicating the degree of polymerisation of said polymer, and Y- is a physiologically acceptable counter ion, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as anti-hypercholesterolaemic agents.

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