C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
167/185, 260/230
C07H 17/08 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2031685
B2881/3005/Abs Abstract A compound of formula (I) or a pharmaceutically acceptable salt thereof: Image (I) wherein: R1 is a group -CH2-X where X is hydrogen, halogen, -CN, -N3, -OC(O)R5, -S(O)nR5, -SH, -OC(O)NHR5, -NHCONHR5 or -NR6R7, where R5 is hydrogen optionally substituted C1-8 alkyl, or aryl, heteroaryl, aryl C1-4 alkyl or heteroaryl C1-4 alkyl in each of which the aromatic moiety is optionally substituted with the proviso that when X is -S(O)nR5, R5 does not represent hydrogen, R6 and R7 are independently hydrogen or C1-6 alkyl, or one of R6 and R7 is hydrogen and the other is -formyl, C2-8 alkanoyl, dialkoxyphosphoryl, aroyl, heteroaroyl, aryl C1-4 alkanoyl, heteroaryl C1-4 alkanoyl, C1-8 alkylsulphonyl, arylsulphonyl, heteroarylsulphonyl, aryl C1-4 alkylsulphonyl or heteroaryl C1-4 alkylsulphonyl, where any aromatic moiety in R6 or R7 is optionally substituted, and n is 0, 1 or 2; R2 is hydroxy or optionally substituted C1-8 alkoxy; R3 is an amino group or a derivative thereof; and each R4 is hydrogen.
Driver Michael J.
Greenlees Alexander R.
Macpherson David T.
Beecham Group P.l.c.
Borden Ladner Gervais Llp
Driver Michael J.
Greenlees Alexander R.
Macpherson David T.
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