C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
167/202, 260/228
C07H 17/00 (2006.01) C07D 498/18 (2006.01) C07D 498/22 (2006.01) C07H 19/01 (2006.01)
Patent
CA 1339128
Compounds of formula I (see fig. I) in which [R1 and R2], [R3 and R4] and [R5 and R6] represent a carbon-carbon bond or two hydrogen atoms; R2 additionally represents alkyl; R7, R8 and R9 represent groups including H or OH, R10 has various significances including alkyl and alkenyl; X and Y represent groups including O and (H,OH); R14, R15, R16, R17, R18, R19, R22 and R23 represent H or alkyl; R20 and R21 represent groups including O, (H,OH) and (H,O-alkyl), n is 1, 2, or 3, and in addition, Y, R10 and R23, together with the carbon atoms to which they are attached, may represent a neterocyclic ring, (with certain provisos) are described. Processes for making the compounds and pharmaceutical formulations containing them, eg for use as immunosuppressive agents, are also described.
585220
Cooper Martin Edward
Donald David Keith
Hardern David Norman
Fisons Plc
Ridout & Maybee Llp
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