Compounds

Details Compounds Compounds

C - Chemistry, Metallurgy

07

D

167/208, 167/269

C07D 207/337 (2006.01) C07C 237/22 (2006.01) C07C 259/06 (2006.01) C07D 207/09 (2006.01) C07D 207/335 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 235/14 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2003719

ABSTRACT COMPOUNDS Compounds of general formula I: Image (I) wherein: R1 represents a hydrogen atom or a C1-C6 alkyl, C1-C6 alkenyl, phenyl, phenyl(C1-C6)alkyl, C1-C6 alkyl- thiomethyl, phenylthiomethyl, substituted phenyl- thiomethyl, phenyl(C1-C6)alkylthiomethyl or heterocyclylthiomethyl group; or R1 represents -SRx wherein Rx represents a group Image ; R2 represents a hydrogen atom or a C1-C6 alkyl, C1-C6 alkenyl, phenyl(C1-C6)alkyl, cycloalkyl(C1- C6)alkyl, or cycloalkenyl(C1-C6)alkyl; R3 represents an amino acid residue with R or S stereochemistry or a C1-C6 alkyl, benzyl, (C1- C6)alkoxybenzyl or benzyloxy(C1-C6)alkyl group; R4 represents a hydrogen atom or a methyl group; n is an integer from 1 to 6; and A represents the group -NH2, a substituted acyclic amine or a heterocyclic base; or a salt and/or N-oxide and/or (where the compound is a thio-compound) a sulphoxide or sulphone thereof have collagenase inhibition activity and are useful in the management of disease involving tissue degradation and/or the promotion of wound healing. Diseases involving tissue degradation include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption diseases and tumour invasion.

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