Compounds

Details Compounds Compounds

C - Chemistry, Metallurgy

07

D

260/100, 260/111

C07D 463/00 (2006.01) C07D 498/04 (2006.01) C07D 499/00 (2006.01) C07D 499/46 (2006.01) C07D 501/57 (2006.01) C07D 505/00 (2006.01)

Patent

CA 2012372

Abstract .beta.-Lactams having the formula (I) or a salt thereof are described, together with a process therefor: Image (I) wherein Y denotes atoms completing a penicillin or cephalosporin - type nucleus, R1 is a group of the formula: HO - [X]n - in which X is an optionally substituted monocyclic or fused polycyclic aromatic ring system in which the attached hydroxy group is conjugated with the group: Image and n is 1 or 2; R2 is hydrogen, C1-6 alkyl or aryl C1-6 alkyl; and R3 is hydrogen or a carboxy protecting group. Compounds of formula (I) are intermediates useful in the preparation of .beta.-lactam antibiotics having an .alpha.-formamido substituent on the carbon atom adjacent to the carbonyl group of the .beta.-lactam ring.

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