Compounds and compositions as channel activating protease...

Details Compounds and compositions as channel activating protease... Compounds and compositions as channel activating protease...

C - Chemistry, Metallurgy

07

K

C07K 5/117 (2006.01) C12N 5/078 (2010.01) A61K 38/06 (2006.01) A61P 11/00 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) C07K 5/107 (2006.01)

Patent

CA 2677485

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

La présente invention concerne des composés et leurs compositions pharmaceutiques, qui servent à moduler les protéases activatrices de canaux, et des procédés destinés à l'utilisation de tels composés afin de traiter, améliorer ou prévenir un état associé à une protéase activatrice de canaux, comprenant mais sans s'y limiter la prostasine, les PRSS22, TMPRSS11 (TMPRSS11B, TMPRSS11E, par exemple), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), la matriptase (MTSP-1), CAP2, CAP3, la trypsine, la cathepsine A ou l'élastase neutrophile.

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