C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/097 (2006.01) A61K 38/06 (2006.01) A61P 11/00 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01)
Patent
CA 2677487
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
La présente invention concerne des composés et des compositions pharmaceutiques de ces composés, qui sont utilisés pour moduler des protéases d'activation de canaux, ainsi que des procédés mettant en oeuvre de tels composés pour traiter, atténuer ou prévenir un état pathologique associé à une protéase d'activation de canaux, par exemple la prostasine, PRSS22, TMPRSS11 (tel que TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), la matriptase (MTSP-1), CAP2, CAP3, la trypsine, la cathepsine A ou l'élastase neutrophile.
Chatterjee Arnab K.
Tully David C.
Wang Zhiwei
Fetherstonhaugh & Co.
Irm Llc
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