Compounds and compositions as channel activating protease...

Details Compounds and compositions as channel activating protease... Compounds and compositions as channel activating protease...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/55 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 11/10 (2006.01) C07K 5/08 (2006.01)

Patent

CA 2651043

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.

L'invention porte sur des composés et leurs préparations pharmaceutiques modulant les protéases d'activation de canaux et sur des méthodes d'utilisation desdits composés pour traiter, améliorer, ou prévenir un état associé à une protéase d'activation de canaux dont, non limitativement,: la prostasine, la PRSS22, la TMPRSS11 (par exemple TMPRSS11B, TMPRSS11E), la TMPRSS2, la TMPRSS3, la TMPRSS4 (MTSP-2), la matriptase (MTSP-1), la CAP2, la CAP3, la trypsine, la cathepsine A, ou l'élastase neutrophile.

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