C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/06 (2006.01) A61K 31/4025 (2006.01) A61K 31/4427 (2006.01) A61K 31/444 (2006.01) A61K 38/05 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01) A61P 29/00 (2006.01) C07K 5/078 (2006.01) A61K 31/401 (2006.01) C12N 9/64 (2006.01) C12N 9/99 (2006.01)
Patent
CA 2673803
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
L'invention concerne des composés et leurs compositions pharmaceutiques, qui sont utiles pour moduler des protéases activatrices de canaux et des procédés d'utilisation de tels composés pour traiter, améliorer ou prévenir une affection associée à une protéase activatrice de canaux y compris, mais sans limitation, la prostasine, la PRSS22, les TMPRSS11 (par exemple, la TMPRSS11B, la TMPRSS11E), la TMPRSS2, la TMPRSS3, la TMPRSS4 (MTSP-2), la matriptase (MTSP-1), la CAP2, la CAP3, la trypsine, la cathepsine A ou l'élastase neutrophile.
Bursulaya Badry
Chatterjee Arnab K.
Spraggon Glen
Tully David C.
Vidal Agnes
Fetherstonhaugh & Co.
Irm Llc
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