Compounds and compositions as hedgehog pathway modulators

Details Compounds and compositions as hedgehog pathway modulators Compounds and compositions as hedgehog pathway modulators

A - Human Necessities

61

K

A61K 31/542 (2006.01) A61K 31/435 (2006.01) A61K 31/437 (2006.01)

Patent

CA 2583812

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss- of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

La présente invention se rapporte à une méthode permettant de moduler l'activité de la voie de signalisation Hedgehog. En particulier, l'invention concerne une méthode permettant d'inhiber des états de croissance aberrante causés par des phénotypes tels que la perte de fonction du gène Ptc, le gain de fonction du gène Hedgehog, le gain de fonction du gène Smoothened ou le gain de fonction du gène Gli. La méthode selon l'invention consiste à mettre une cellule en contact avec une quantité suffisante d'un composé représenté par la formule (I).

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