Compounds and compositions as hedgehog pathway modulators

Details Compounds and compositions as hedgehog pathway modulators Compounds and compositions as hedgehog pathway modulators

C - Chemistry, Metallurgy

07

D

C07D 233/64 (2006.01) A61K 31/4164 (2006.01) A61K 31/4709 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2658782

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

L'invention porte sur une méthode de modulation de l'activité du mécanisme de signalisation Hedgehog, et en particulier sur une méthode inhibant les états aberrants de croissance tels que: la perte de fonction Ptc; le gain de fonction Hedgehog; le gain de fonction de la protéine Smoothened ou gain de fonction Gli, consistant à mettre en contact une cellule avec une quantité suffisante d'un composé de formule (I).

Affiliated with

Also associated with

Rating

Compounds and compositions as hedgehog pathway modulators does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds and compositions as hedgehog pathway modulators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds and compositions as hedgehog pathway modulators will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1993065