Compounds and compositions as itpkb inhibitors

Details Compounds and compositions as itpkb inhibitors Compounds and compositions as itpkb inhibitors

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/536 (2006.01) A61P 37/02 (2006.01) C07D 413/02 (2006.01)

Patent

CA 2688487

The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1, 4, 5- trisphosphate 3 -kinase B (ITPKb).

L'invention concerne une nouvelle famille de composés de la formule (I), des compositions pharmaceutiques comprenant de tels composés et des procédés d'utilisation de tels composés pour traiter ou empêcher des maladies ou des troubles associés des activités de cellules B anormales ou dérégulées, en particulier des maladies ou des troubles qui impliquent une activation anormale d'inositol 1,4,5-trisphosphate-3-kinase B (ITPKb).

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