Compounds and compositions as kinase inhibitors

Details Compounds and compositions as kinase inhibitors Compounds and compositions as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01)

Patent

CA 2713807

The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity,particulary Syk,ZAP70,KDR,FMS,FLT*,c- Kit,RET,TrkA,TrkB,TrkC-GR-1R Alk,c- FMS.or combinations thereof.

L'invention porte sur une nouvelle classe de dérivés de 2,7-naphthydrine; sur des compositions pharmaceutiques comportant de tels composés et sur des procédés d'utilisation de tels composés pour traiter ou prévenir des maladies ou des troubles associés à une activité kinase anormale ou dérégulée, en particulier de Syk ZAP70, KDR, FMS, FLT*, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk,c- FMS ou de leurs combinaisons.

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