Compounds and compositions as kinase inhibitors

Details Compounds and compositions as kinase inhibitors Compounds and compositions as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2696824

The invention provides novel pyrimidine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-1R) or anaplastic lymphoma kinase (ALK).

L'invention porte sur de nouveaux dérivés de pyrimidine et sur des compositions pharmaceutiques de ceux-ci, ainsi que sur des procédés d'utilisation de tels composés. Par exemple, les dérivés de pyrimidine de l'invention peuvent être utilisés pour traiter, améliorer ou prévenir une condition qui répond à l'inhibition du facteur de croissance de type insuline (IGF-1R) ou de la kinase de lymphome anaplasique (ALK).

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