Compounds and compositions as kinase inhibitors

Details Compounds and compositions as kinase inhibitors Compounds and compositions as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2720944

The invention relates to triazine and pyrimidine derivatives having Formula (1) or (2), and methods for using such compounds. For example, the compounds of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, c-ros oncogene (ROS), insulin-like growth factor (IGF-IR), and/or insulin receptor (InsR) or a combination thereof.

L'invention concerne des dérivés de triazine et de pyrimidine de formule (1) et (2), et des procédés d'utilisation de tels composés. Par exemple, les composés de l'invention peuvent être utilisés pour traiter, améliorer ou prévenir un trouble qui répond à l'inhibition de l'activité de la kinase du lymphome anaplasique (ALK), de l'oncogène c-ros (ROS), du facteur de croissance analogue à l'insuline (IGF-IR) et/ou du récepteur de l'insuline (InsR) ou une de leurs combinaisons.

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