Compounds and compositions as kinase inhibitors

Details Compounds and compositions as kinase inhibitors Compounds and compositions as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2729546

The invention" provides novel pyrimidine derivatives of formula (I) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK).

La présente invention concerne de nouveaux dérivés de pyrimidine et des compositions pharmaceutiques de ceux-ci, ainsi que des procédés dutilisation de ces composés. Par exemple, les dérivés de pyrimidine de linvention peuvent être utilisés pour traiter, améliorer ou prévenir une pathologie sensible à linhibition du facteur de croissance insulinomimétique (IGF-1R) ou de la kinase du lymphome anaplasique (ALK).

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