Compounds and compositions as modulators of gpr119 activity

Details Compounds and compositions as modulators of gpr119 activity Compounds and compositions as modulators of gpr119 activity

C - Chemistry, Metallurgy

07

D

C07D 211/44 (2006.01) A61K 31/497 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2720950

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119; such as, but not limited to, diabetes, obesity and associated metabolic disorders. Formula (I) is a compound, in which A can have up to 2 ring -CH2- group substituted with -C(O)- and can be partially unsaturated with up to 2 double bonds; W i and W2 are independently selected from CR10 and N; wherein R10 is selected from hydrogen and C1_6alkyl; Yi is selected from NRn, O and S; wherein Rn is selected from hydrogen and C1-6alkyl; Y2 and Y3 are independently selected from CH and N; Y4 is selected from CH2, OCH2 and NR15; wherein R15 is selected from hydrogen and C1_6alkyl; or the pharmaceutically acceptable salts thereof.

Linvention concerne des composés, ou des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques comprenant de tels composés et des procédés dutilisation de tels composés pour traiter ou prévenir des maladies ou des troubles associés à lactivité de GPR119, ces maladies ou troubles comprenant, de manière non limitative, le diabète, l'obésité et des troubles métaboliques associés. La formule (I) correspond à un composé dans lequel A peut présenter jusqu'à 2 groupes -CH2- annulaires substitués par -C(O)- et peut être partiellement insaturé avec jusqu'à 2 liaisons doubles; Wi et W2 sont indépendamment sélectionnés parmi CR10 et N; R10 étant sélectionné parmi hydrogène et alkyle C1_6; Yi étant sélectionné parmi NRn, O et S; Rn étant sélectionné parmi hydrogène et alkyle C1_6; Y2 et Y3 étant indépendamment sélectionnés parmi CH et N; Y4 étant sélectionné parmi CH2, OCH2 et NR15; R15 étant sélectionné parmi hydrogène et alkyle C1_6.

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